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Efficient ex vivo expansion of cd4amp;plus; and cd8amp;minus; T-cells from HIV infected subjects
Efficient ex vivo expansion of cd4amp;plus; and cd8amp;minus; T-cells from HIV infected subjects
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机译:cd4 + plus的高效离体扩增;和cd8− HIV感染者的T细胞
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摘要
Methods for the expansion of CD4, CD8, and DP T-cells from HIV infected patients are disclosed which allow the maintenance of low levels of HIV. The invention further discloses methods for the inhibition of HIV gene expression. Also disclosed are methods for the rapid and efficient screening of cells derived from HIV-infected patients to assess the suitability of various antiviral treatments. The invention further provides a means for the generation of cell banks for use in immune reconstitution and means of treating or modifying expanded cell populations prior to infusion to enhance or modulate therapeutic effectiveness.
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