T(H)17 cells mediate inflammation in a novel model of spontaneous experimental autoimmune lacrimal keratoconjunctivitis with neural damage

Seo Kyoung Yul; Kitamura Kazuya; Han Soo Jung; Kelsall Brian

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T(H)17 cells mediate inflammation in a novel model of spontaneous experimental autoimmune lacrimal keratoconjunctivitis with neural damage

机译：T（h）17细胞在神经损伤中介导自发实验性自身免疫泪腺炎的新型模型中的炎症

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Background: Dry eye disease (DED) affects one third of the population worldwide. In prior studies, experimental autoimmune lacrimal keratoconjunctivitis (EALK) induced by desiccating stress in mice has been used as a model of DED. This model is complicated by a requirement for exogenous epithelial cell injury and administration of anticholinergic agents with broad immunologic effects.

机译：背景：干眼症（DED）影响全世界的三分之一。在先前的研究中，通过干燥小鼠胁迫引起的实验性自身免疫角膜衰颈（EALK）已被用作DED的模型。该模型对外源上皮细胞损伤和抗胆碱能药物的要求复杂化了宽免疫效应。

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来源
《The Journal of Allergy and Clinical Immunology》 |2018年第1期|共15页
作者
Seo Kyoung Yul; Kitamura Kazuya; Han Soo Jung; Kelsall Brian;
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作者单位

NIAID Mucosal Immunobiol Sect Lab Mol Immunol NIH 9000 Rockville Pike Bethesda MD 20892 USA;

NIAID Mucosal Immunobiol Sect Lab Mol Immunol NIH 9000 Rockville Pike Bethesda MD 20892 USA;

Yonsei Univ Coll Med Dept Ophthalmol Inst Vis Res Seoul South Korea;

NIAID Mucosal Immunobiol Sect Lab Mol Immunol NIH 9000 Rockville Pike Bethesda MD 20892 USA;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
Autoimmune lacrimal keratoconjunctivitis; T(H)17 cell;

机译：自身免疫性泪室角膜皮膜诊断;T（h）17细胞;

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1. T(H)17 cells mediate inflammation in a novel model of spontaneous experimental autoimmune lacrimal keratoconjunctivitis with neural damage [J] . Seo Kyoung Yul, Kitamura Kazuya, Han Soo Jung, The Journal of Allergy and Clinical Immunology . 2018,第1期

机译：T（h）17细胞在神经损伤中介导自发实验性自身免疫泪腺炎的新型模型中的炎症
2. Ocular surface APCs are necessary for autoreactive T cell-mediated experimental autoimmune lacrimal keratoconjunctivitis. [J] . Schaumburg CS, Siemasko KF, De Paiva CS, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2011,第7期

机译：眼表APC对于自身反应性T细胞介导的实验性自身免疫性泪道角膜结膜炎是必需的。
3. STA-21, a Promising STAT-3 Inhibitor That Reciprocally Regulates Th17 and Treg Cells, Inhibits Osteoclastogenesis in Mice and Humans and Alleviates Autoimmune Inflammation in an Experimental Model of Rheumatoid Arthritis [J] . Park Jin-Sil, Kwok Seung-Ki, Lim Mi-Ae, Arthritis & rheumatology. . 2014,第4期

机译：STA-21，一种有前途的STAT-3抑制剂，可相互调节Th17和Treg细胞，在类风湿关节炎实验模型中抑制小鼠和人类的破骨细胞生成并减轻自身免疫炎症。
4. Rotating Magnetic Field Ameliorates Experimental Autoimmune Encephalomyelitis by Promoting T cell Peripheral Accumulation and Regulating the Balance of Treg and TH1/TH17 [C] . Tianying Zhan, Xiaomei Wang, Zijun Ouyang, The 8th International Conference on Magneto- Science（第八届国际磁科学会议）论文集 . -1

机译：旋转磁场通过促进T细胞周围积累和调节Treg和Th1 / Th17的平衡来改善实验性自身免疫性脑炎。
5. CD43 Dependent Mechanisms of Th17 Cell Recruitment to Sites of Inflammation and Autoimmune Reactions. [D] . Velazquez Planas, Francisco Esteban. 2017

机译：Th17细胞募集到炎症和自身免疫反应部位的CD43依赖性机制。
6. Therapeutic Effect of Ginsenoside Rd on Experimental Autoimmune Encephalomyelitis Model Mice: Regulation of Inflammation and Treg/Th17 Cell Balance [O] . Bo Jin, Chixiao Zhang, Yu Geng, 2020

机译：人参皂苷Rd对实验性自身免疫脑脊髓炎模型小鼠的治疗作用：炎症和Treg / Th17细胞平衡的调节
7. Inhibition of Myeloperoxidase by N-Acetyl Lysyltyrosylcysteine Amide Reduces Oxidative Stress–Mediated Inflammation, Neuronal Damage, and Neural Stem Cell Injury in a Murine Model of Stroke [O] . Guoliang Yu, Ye Liang, Shikan Zheng, 2017

机译：N-乙酰溶溶酶酰胺酰胺抑制肌髓氧基酶酰胺可减少氧化应激介导的血鼠模型中氧化应激介导的炎症，神经元损伤和神经干细胞损伤

T(H)17 cells mediate inflammation in a novel model of spontaneous experimental autoimmune lacrimal keratoconjunctivitis with neural damage

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