Copper-catalyzed direct oxidative C(sp(2))-H alpha-sulfenylation of enaminones with disulfides or thiophenols: Synthesis of polyfunctionalized aminothioalkenes

摘要

A copper(II)-catalyzed protocol for the construction of aminothioalkenes has been achieved that is based on the reaction of enaminones with disulfides/thiophenols in the presence of tert-butyl hydroperoxide (TBHP) to give good to excellent yields. This study provides a new strategy for the formation of C (sp(2))-S bonds via direct alpha-sulfenylation of C(sp(2))-H bonds. (C) 2018 Elsevier Ltd. All rights reserved.