A Rh(lll)-Catalyzed Cascade C-H Functionalization/C(sp3)-C(sp3) Formation/Cyclization Reaction for the Synthesis of Isoquinoline-dione Derivatives

摘要

A cascade C-H functionalization/C(sp3)-C(sp3) forma-tion/cyclization reaction of /V-methoxybenzamides with diazomal-onates under rhodium(lll) catalysis is developed for the efficient synthesis of isoquinolinedione derivatives. A plausible mechanism involving double migratory insertions of carbenes for the formation of C(sp2)-C(sp3) and C(sp3)-C(sp3) bonds by rhodium(lll) catalysis is also proposed.