Copper-Catalyzed Cleavage of Unstrained C-C Bonds for the Synthesis of 1-Acyloxy-2,2,6,6-tetramethylpiperidines from Cyclic or Acyclic Ketones

摘要

A copper-catalyzed approach for the synthesis of 1-acyloxy2,2,6,6-tetramethylpiperidines through the C-C bond cleavage of cyclic or acyclic ketones was developed. In this chemistry, a combination of CuCl2 center dot 2H(2)O,1,10-phenanthroline monohydrate, and aniline was crucial for the formation of the desired products by the reaction of ketones with TEMPO. This research provides a new strategy for the further transformation of alpha-aryl cyclic or acyclic ketones.