Copper-Catalyzed Aerobic Oxidative C-C Bond Cleavage of Unstrained Ketones with Air and Amines

摘要

A unique copper-catalyzed aerobic oxidative C-C bond cleavage of simple unstained ketones with air and amines has been developed. In this chemistry, amides and oxo amides are easily synthesized through-the selective C-C bond cleavage of simple ketones or unstained. cycloketones. The broad substrate scopes and use of an inexpensive copper catalyst and green molecular oxygen as an oxidant as well as an O-source make this protocol very attractive for potential synthetic applications. The control experiments reveal that the present copper-catalyzed oxidative C-C bond cleavage of simple ketones proceeds in a novel catalytic pathway rather than through the cleavage of a dioxetane intermediate.