Selected Mutations Revealed Intermediates and Key Precursors in the Biosynthesis of Polyketide-Terpenoid Hybrid Sesquiterpenyl Epoxy-cyclohexenoids

摘要

Sesquiterpenyl epoxy-cydohexenoids (SECs) show impressive biological activities. However, the key pathways for SECs still remain, unambiguous. Unexpectedly, 11 new SECs and derivatives with diverse oxidation patterns were isolated after the deletion of gene 274. A high accumulation of toluquiriol and its new glycosides in mutant Delta 276 and further isolation of the most crucial. precursors farnesy1 hydroquinone, farnesyl quinone, and three new derivatives froth mutant Delta 278-confirm that farnesylation at toluquinol is the key step for SECs.