A poly(amidoamine) dendrimer-based drug carrier for delivering DOX to gliomas cells

Li Yan; He Hai; Lu Wanliang; Jia Xinru

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A poly(amidoamine) dendrimer-based drug carrier for delivering DOX to gliomas cells

机译：基于聚（氨基胺）的树枝状聚合物的药物载体，用于将DOX递送给GLIIMAS细胞

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A drug delivery carrier G4-FA-PEG with PEG and FA modified on the periphery of G4.0 poly(amidoamine) (PAMAM) dendrimer was synthesized, and doxorubicin (DOX) was encapsulated in the interior. The in vitro cytotoxicity and cellular uptake in gliomas cells were both enhanced via a FR-mediated endocytosis pathway.

机译：用PEG和Fa在G4.0聚（酰胺）（酰胺）树枝状聚合物的周边上用PEG和Fa改变的药物递送载体G4-FA-PEG，并将多柔比星（DOX）包封在内部。通过FR介导的内吞作用途径增强了胶质瘤细胞中的体外细胞毒性和细胞摄取。

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《RSC Advances》 |2017年第25期|共7页
作者
Li Yan; He Hai; Lu Wanliang; Jia Xinru;
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作者单位

Hebei Univ Engn Coll Mat Sci &

Engn Handan 056038 Peoples R China;

Peking Univ Key Lab Polymer Chem &

Phys Beijing Natl Lab Mol Sci Minist Educ Coll Chem &

Mol Engn Beijing 100871 Peoples R China;

Peking Univ State Key Lab Nat &

Biomimet Drugs Beijing Peoples R China;

Peking Univ Key Lab Polymer Chem &

Phys Beijing Natl Lab Mol Sci Minist Educ Coll Chem &

Mol Engn Beijing 100871 Peoples R China;

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正文语种 eng
中图分类化学;
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专利

1. A poly(amidoamine) dendrimer-based drug carrier for delivering DOX to gliomas cells [J] . Li Yan, He Hai, Lu Wanliang, RSC Advances . 2017,第25期

机译：基于聚（氨基胺）的树枝状聚合物的药物载体，用于将DOX递送给GLIIMAS细胞
2. PEGylated poly(amidoamine) dendrimers-based drug loading vehicles for delivering carboplatin in treatment of various cancerous cells [J] . Minh Nhat Ho, Long Giang Bach, Thi Hiep Nguyen, Journal of nanoparticle research: An interdisciplinary forum for nanoscale science and technology . 2019,第2期

机译：基于聚乙二醇化的聚（酰胺胺）树枝状原型的药物载体，用于递送卡铂治疗各种癌细胞
3. Cellular uptake of glucoheptoamidated poly(amidoamine) PAMAM G3 dendrimer with amide-conjugated biotin, a potential carrier of anticancer drugs [J] . Uram Lukasz, Szuster Magdalena, Filipowicz Aleksandra, Bioorganic and medicinal chemistry . 2017,第2期

机译：葡聚糖酰胺化聚（酰胺胺）PAMAM G3树枝状聚合物与酰胺缀合的生物素，抗癌药物的潜在载体的细胞吸收
4. DEVELOPMENT OF THE MIXED MICELLES THAT DELIVER MULTIPLE DRUGS DOXORUBICIN (DOX) AND WORTMANNIN (WOR) SIMULTANEOUSLY FOR COMBINATION CANCER CHEMOTHERAPY [C] . Y. Bae, T. Diezi, A. Zhao, Controlled Release Society Annual Meeting and Exposition . 2007

机译：同时混合多种药物阿霉素（WOX）和渥曼青霉素（WOR）的混合胶束的开发
5. Poly (amidoamine) dendrimers as oral drug carriers. [D] . Kitchens, Kelly Marie. 2007

机译：聚（酰胺基胺）树状聚合物作为口服药物载体。
6. Stepwise Glucoheptoamidation of Poly(Amidoamine) Dendrimer G3 to Tune Physicochemical Properties of the Potential Drug Carrier: In Vitro Tests for Cytisine Conjugates [O] . Anna Czerniecka-Kubicka, Piotr Tutka, Marek Pyda, 2020

机译：逐步葡聚糖酰胺的聚（酰胺胺）树突G3曲调潜在药物载体的物理化学性质：细胞苷缀合物的体外试验
7. Poly(amidoamine) dendrimer–drug conjugates with disulfide linkages for intracellular drug delivery [O] . Yunus E. Kurtoglu, Raghavendra S. Navath, Bing Wang, 2009

机译：聚（酰胺胺）树枝状二聚体 - 药物缀合物，用于细胞内药物递送的二硫键

A poly(amidoamine) dendrimer-based drug carrier for delivering DOX to gliomas cells

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