Multimodal mechanistic signatures for neurodegenerative diseases (NeuroMMSig): a web server for mechanism enrichment

Domingo-Fernandez Daniel; Kodamullil Alpha Tom; Iyappan Anandhi; Naz Mufassra; Emon Mohammad Asif; Raschka Tamara; Karki Reagon; Springstubbe Stephan; Ebeling Christian; Hofmann-Apitius Martin

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Multimodal mechanistic signatures for neurodegenerative diseases (NeuroMMSig): a web server for mechanism enrichment

机译：神经变性疾病的多式式机制签名（Neurommsig）：一种机制富集的Web服务器

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摘要

The concept of a 'mechanism-based taxonomy of human disease' is currently replacing the outdated paradigm of diseases classified by clinical appearance. We have tackled the paradigm of mechanism-based patient subgroup identification in the challenging area of research on neurodegenerative diseases.

机译：“人类疾病的机制基础分类”的概念目前取代了临床外观归类的过时的疾病范式。我们解决了基于机制的患者亚组识别范式，在挑战性的神经退行性疾病研究领域。

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《Bioinformatics》 |2017年第22期|共3页
作者
Domingo-Fernandez Daniel; Kodamullil Alpha Tom; Iyappan Anandhi; Naz Mufassra; Emon Mohammad Asif; Raschka Tamara; Karki Reagon; Springstubbe Stephan; Ebeling Christian; Hofmann-Apitius Martin;
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作者单位

Fraunhofer Inst Algorithms &

Sci Comp Dept Bioinformat D-53754 St Augustin Germany;

Fraunhofer Inst Algorithms &

Sci Comp Dept Bioinformat D-53754 St Augustin Germany;

Fraunhofer Inst Algorithms &

Sci Comp Dept Bioinformat D-53754 St Augustin Germany;

Fraunhofer Inst Algorithms &

Sci Comp Dept Bioinformat D-53754 St Augustin Germany;

Fraunhofer Inst Algorithms &

Sci Comp Dept Bioinformat D-53754 St Augustin Germany;

Fraunhofer Inst Algorithms &

Sci Comp Dept Bioinformat D-53754 St Augustin Germany;

Fraunhofer Inst Algorithms &

Sci Comp Dept Bioinformat D-53754 St Augustin Germany;

Fraunhofer Inst Algorithms &

Sci Comp Dept Bioinformat D-53754 St Augustin Germany;

Fraunhofer Inst Algorithms &

Sci Comp Dept Bioinformat D-53754 St Augustin Germany;

Fraunhofer Inst Algorithms &

Sci Comp Dept Bioinformat D-53754 St Augustin Germany;

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正文语种 eng
中图分类生物工程学（生物技术）;
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1. Multimodal mechanistic signatures for neurodegenerative diseases (NeuroMMSig): a web server for mechanism enrichment [J] . Domingo-Fernandez Daniel, Kodamullil Alpha Tom, Iyappan Anandhi, Bioinformatics . 2017,第22期

机译：神经变性疾病的多式式机制签名（Neurommsig）：一种机制富集的Web服务器
2. KOBAS 2.0: a web server for annotation and identification of enriched pathways and diseases [J] . Chen Xie, Chuan-Yun Li, Ge Gao, Nucleic acids research . 2011,第suppla2期

机译：KOBAS 2.0：用于注释和识别丰富途径和疾病的Web服务器
3. miRTrail - a comprehensive webserver for analyzing gene and miRNA patterns to enhance the understanding of regulatory mechanisms in diseases [J] . Cedric Laczny, Petra Leidinger, Jan Haas, BMC Bioinformatics . 2012,第1期

机译：miRtrail - 一种综合网络服务器，用于分析基因和miRNA模式，以提高对疾病的监管机制的理解
4. Early Diagnosis of Neurodegenerative Diseases by Handwritten Signature Analysis [C] . Giuseppe Pirlo, Moises Diaz, Miguel Angel Ferrer, International conference on image analysis and processing;International workshop on recent advances in digital security: biometrics and forensics;Workshop on color in texture and material recognition;Workshop on medical imaging in rheumatology: advanced applications for the analysis of inflammation and damage in the rheumatoid joint;Workshop on image-based smart city application;International workshop on multimedia assisted dietary management;Workshop on scene background modeling and initalization;workshop on image and video processing for quality of multimedia experience . 2015

机译：手写签名分析对神经退行性疾病的早期诊断
5. Characterizing the Huntington's disease, Parkinson's disease, and pan-neurodegenerative gene expression signature with RNA sequencing [D] . Labadorf, Adam Thomas 2016

机译：利用RNA测序表征亨廷顿氏病，帕金森氏病和泛神经变性基因表达特征
6. Multimodal mechanistic signatures for neurodegenerative diseases (NeuroMMSig): a web server for mechanism enrichment [O] . Daniel Domingo-Fernández, Alpha Tom Kodamullil, Anandhi Iyappan, -1

机译：神经退行性疾病的多峰机制特征（NeuroMMSig）：机制丰富的Web服务器
7. miRTrail - a comprehensive webserver for analyzing gene and miRNA patterns to enhance the understanding of regulatory mechanisms in diseases [O] . Laczny Cedric, Leidinger Petra, Haas Jan, 2012

机译：miRTrail-用于分析基因和miRNA模式的综合网络服务器，可增强对疾病调节机制的了解

Multimodal mechanistic signatures for neurodegenerative diseases (NeuroMMSig): a web server for mechanism enrichment

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