Polyelectrolyte complex of carboxymethyl gum katira-chitosan: Preparation and characterization

摘要

Highlights?Polyelectrolyte complex of carboxymethyl gum katira and chitosan were prepared and characterized.?Preparation of polyelectrolyte complexes were optimized using 2-factor 3-level CCD using ofloxacin as model drug.?Polyelectrolyte complex sustainedin vitrorelease of ofloxacin over 24h.?Polyelectrolyte complex showed anti-microbial activity comparable to ofloxacin solution.AbstractIn the present study polyelectrolyte complex between carboxymethyl gum katira and chitosan were prepared and evaluated for drug delivery using ofloxacin as model drug. The carboxymethyl gum katira-chitosan polyelectrolyte complex was characterized by FTIR, DSC, TGA, DTG, XRD and SEM. The influence of concentration of CMGK/CH and drug loading (%) on yield (%) and drug entrapment (%) was studied using response surface methodology. The result of the study revealed that increasing the relative prop