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Preparation and characterization of O-carboxymethyl chitosan-sodium alginate polyelectrolyte complexes

机译:O-羧甲基壳聚糖-海藻酸钠聚电解质配合物的制备与表征

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摘要

O-carboxymethyl chitosan (O-CMC) is a water-soluble derivative of chitosan. In this work, the formation of polyelectrolyte complex (PEC) between O-CMC and sodium alginate (SAL) was explored by investigating the effects of medium pH, polyelectrolytes mixing ratio, and ionic strength on the yield of O-CMC-SAL PECs. Meanwhile, the rheological, thermal, and microstructural properties of the PECs prepared at various medium acidities were characterized as well. The results indicated that the strongest complexation between O-CMC and SAL occurred in medium pH 6.5 and biopolymer ratio (R (O-CMC/SAL)) 1.5:1 (w/w) in the absence of added NaCl. Fourier transform infrared (FTIR) spectroscopy analysis revealed that both electrostatic interaction and hydrogen bonding were involved in PEC formation. The PECs possessed the porous structure and displayed predominately the elastic property with the highest moduli values being recorded at medium pH 3.5. It was concluded that the O-CMC-SAL PECs have potential biomedical applications due to the nearly neutral complexation pH and the porous structure for drug inclusion.
机译:O-羧甲基壳聚糖(O-CMC)是壳聚糖的水溶性衍生物。在这项工作中,通过研究中等pH,聚电解质混合比和离子强度对O-CMC-SAL PECs收率的影响,探索了O-CMC和藻酸钠(SAL)之间的聚电解质复合物(PEC)的形成。同时,还表征了在各种中等酸性条件下制备的PEC的流变,热和微观结构性质。结果表明,在不添加NaCl的情况下,中等pH值6.5和生物聚合物比(R(O-CMC / SAL))为1.5:1(w / w)时,O-CMC和SAL之间的最强络合发生。傅里叶变换红外(FTIR)光谱分析表明,静电相互作用和氢键均参与PEC的形成。 PEC具有多孔结构并主要表现出弹性性能,在中等pH 3.5时记录的模量值最高。结论是,O-CMC-SAL PEC由于接近中性的络合pH和药物包埋的多孔结构而具有潜在的生物医学应用。

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