in vitro Antimicrobial Activity and in silico Activity of 1-Thiocarbamoyl Substituted Pyrazole Derivatives

摘要

A convenient synthesis of l-thiocarbamoyl-3-phenyl-5-diphenyl-4,5-dihydro-(1H)-pyrazole derivatives (2a-2g) was carried out by the condensation reaction of (E)-3-(phenyl)-l-(biphenyl-2-yl)-3-arylprop-2-en-l-ones (la-lg) with thiosemicarbazide, sodium hydroxide as a catalyst in the presence of ethanol as solvent. Further, (E)-3-(phenyl)-1-(biphenyl-2-yl)-3-arylprop-2-en-l-ones were synthesized by the Claisen-Schmidt condensation reaction of substituted aldehydes with 4-acetylbiphenyl in the presence of basic ethanolic solution. The structure of synthesized compounds were confirmed by FT-IR, 'H NMR, ~(13)C NMR and ~1H-~1H COSY. The antimicrobial susceptibility tests of synthesized compounds were screened against Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli and Pseudomonas aeruginosa. The docking studies also carried out by using 1UAG receptor for all the synthesized compounds (2a-2g).