Di-cationic Ionic Liquid Catalyzed Synthesis of 1,5-Benzothiazepines

摘要

A simple and elegant method for the synthesis of 1,5-benzotbiazepines has been developed using di-cationic liquid as a solvent cum catalyst by the reaction of o-aminothiophenol with a variety of chalcones under mild reaction conditions. Furthermore the reusability of the catalyst has also been studied for three cycles. All the reactions are proposed to proceed through a 1,4-conjugate Michael addition followed by a cyclo-condensation reaction.