羧基功能化离子液体催化合成1,5-苯并二氮衍生物

摘要

在无溶剂条件下,以邻苯二胺和丙酮为原料,羧基功能化离子液体CmmimBF_4(IL)为催化剂,合成了1,5-苯并二氮衍生物(2),其结构经~1H NMR和IR表征.在IL用量为10 mol%,于40 ℃反应1.5 h的条件下,2的产率达93%.IL无需再生处理,可连续循环使用5次,且活性无明显下降.%Using a carboxyl-functionalized ionic liquid[CmmimBF_4(IL)] as a novel reusable catalyst, 1,5-benzodiazepine derivative(2) was synthesized by the condensation of o-phenylenediamine with acetone in the absence of solvent. The yield of 2 was 93% at the reaction conditions of 10 mol% IL and at 40 ℃ for 1.5 h. IL can be reused five times continuously without a significant decrease in activity. The structure was characterized by ~1H NMR and IR.