Synthesis of New 2-Amino-6-(4-hydroxy-2-oxo-chromen-3-yI)-4-aryl Nicotine Nitrile in Eco-Friendly Media and their Antimicrobials and DPPH Radical Scavenging Activities

摘要

A simple,green,efficient and economical procedure for the synthesis of,2-amino-6-(4-hydroxy-2-oxo-chromen-3-yl)-4-(aryl)nicotine nitrile(4a-g)by two routes carried in same conditions,have been reported.The new compounds 4a-g were characterized by ~1H NMR,~(13)C NMR,FT-IR and elemental analysis.The synthesized compounds were screened for their antibacterial activities against Gram-positive bacterial strains(Micrococcus luteus LB 14110,Staphylococcus aureus ATCC 6538,Listeria monocytogenes ATCC 19117),Gram-negative bacteria(Escherichia coli,Salmonella typhimurium ATCC 14028 and Pseudomonas aeruginosa).The coumarin derivative 4a and 3-acetyl-4-hydroxycouamrin(1)were the most active against two bacteria Staphylococcus aureus ATCC 6538 and Candida albicans respectively.The best minimum inhibitory concentration values were obtained for the compound 4a against Candida albicans(0.0195 g/cm~3).In addition,compounds 4a-g were investigated for their antioxidant activities by DPPH(2,2-diphenyl-l-picrylhydrazyl)in which most of them displayed significant antioxidant activities.