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Impact of age on male fertility

机译:年龄对男性生育力的影响

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PURPOSE OF REVIEW: An increasing number of older men are seeking help for fathering a child, but male fertility gradually declines with age. This review highlights changes in male reproductive biology and practical clinical concerns for aging men. RECENT FINDINGS: Aging may have an impact on sperm DNA damage such as single nucleotide polymorphisms. A recent landmark study identified that the number of single gene de-novo mutations in the offspring increased by two mutations per year based on paternal age. Additionally, advanced paternal age has been linked with neurocognitive disorders such as autism and schizophrenia. For the management of hypogonadism, strategies using selective estrogen modulators have been increasingly utilized to maintain fertility potential. SUMMARY: Aging has an impact on male fertility potential, as well as potential genetic effects for the offspring.
机译:审查目的:越来越多的老年男子正在寻求帮助育儿,但是男性的生育能力随着年龄的增长而逐渐下降。这篇综述着重介绍了男性生殖生物学的变化以及老年男性的实际临床问题。最新发现:衰老可能会对精子DNA损伤(例如单核苷酸多态性)产生影响。最近的一项具有里程碑意义的研究表明,后代中单基因的de-novo突变数量每年根据父本年龄增加两个突变。另外,父亲的高龄与神经认知障碍如自闭症和精神分裂症有关。为了控制性腺功能减退症,使用选择性雌激素调节剂的策略已越来越多地用于维持生育能力。摘要:衰老对男性生育能力以及对后代的潜在遗传影响都有影响。

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