Preparation and Thermal Characterization of Poly(ethylene oxide)/Griseofulvin Solid Dispersions for Biomedical Applications

摘要

In this work, a series of poly(ethylene oxide)/griseofulvin (PEO/gris) solid dispersions has been prepared and characterized by PLM, FTIR, DSC, and MT-DSC. It has been found that the crystalline phase morphology depends strongly on the PEO molecules stay in amorphous phase of PEO, which enhances the solubility of a drug and increases its biological access. For PEO-drug systems containing 5, 10, and 15% gris, FTIR bands due to stretching vibrations of the O-H groups were found at 3436, 3436, and 3413 cm(-1), respectively, whereby for pure PEO 3400, they were located at 3513 cm(-1)-the observed shift proves the existence of hydrogen bonds between PEO and griseofulvin. The presence of griseofulvin caused lowering of the systems' melting temperature in the whole concentration range and, as evidenced by MT-DSC results, recrystallization of PEO in the PEO/griseofulvin systems during melting does occur. (c) 2008 Wiley Periodicals, Inc. J Appl Polym Sci 111: 1690-1696, 2009