Comment on Hydroxytyrosol Induces Proliferation and Cytoprotection against Oxidative Injury in Vascular Endothelial Cells: Role of Nrf2 Activation and HO-1 Induction

摘要

In their recent publication in this Journal, Zrelli et al. describe the induction of proliferation and cytoprotection against oxidative injury by the olive oil constituent hydroxytyrosol (HT). The addition of HT in the range of 50—100 μM, to porcine vascular endothelial cells (PVECs) increased cell proliferation, improved wound repair, and rendered cells partly resistant to H2O2-induced cytotoxicity. On the basis of subsequent experiments, the authors argue that HT up-regulates the antioxidant defense system in PVECs through the activation of Nrf2-con-trolled enzymes, in particular, heme oxygenase-1 (HO-1).