Mortality risk among middle-aged women with first atrial fibrillation.

摘要

Why was the mortality risk greater once AF was identified? Conen et al suggest that the increased risk was at least partly mediated through nonfatal cardiovascular events such as congestive heart failure and stroke, as has been reported by others.6-7 Conen et al also observed an association between incident AF and myocardial infarction,1 which was thought to also contribute to an increased mortality risk among these women. This observation is consistent with results of the Olmsted County AF study, in which a strong relationship between incident AF and subsequent coronary events was observed,8 and extends the evidence of this relationship to younger women. In the Olmsted County study, incident AF was associated with substantially higher risk of coronary events in women than that predicted by the Framingham risk score, with the excess mortality risk significantly greater among women than men.