NSAIDs increase CV risk long-term

摘要

Cardiovascular risk cannot be disregarded when prescribing non-steroidal antiinflammatory drugs (NSAIDs), the authors of a meta-analysis have concluded (online in the BMJ, 11 January 2011). Most studies they reviewed showed some evidence of an increased CV risk, with rofecoxib associated with the highest risk of myocardial infarction (rate ratio 2.12, 95 per cent credibility interval 1.26-3.56) and ibuprofen (3.36, 95 per cent CrI 1-11.6) with the highest risk of stroke when compared with placebo. Etoricoxib (4.07,95 per cent CrI 1.23-15.7) and diclofenac (3.98, 95 per cent CrI 1.48-12.7) were associated with the highest risk of cardiovascular death.Naproxen was found to be the least harmful of seven NSAIDs analysed.