method for treating a patient's risk of developing an ulcer associated with nsaids

摘要

the present invention relates to a method for the treatment of a disease or disorder in a patient at risk of developing an ulcer associated with nsaid for the administration of a pharmaceutical composition in the form of a unit dose comprising naproxen, or a salt pharmaceutiquemen it is acceptable, and esomeprazole, a pharmaceutically acceptable salt thereof.the dosage unit is designed to release at least a portion of the esomeprazole regardless of ph (e.g., at a ph greater than or equal to 0), and naproxen is released only when the ph and the surrounding medium is equal to or greater than 3.5.