Novel targeted approach for prostate cancer tested

摘要

A new,targeted RNA therapy has been shown to be effective in a mouse model of prostate cancer,according to research published online in Nature Biotechnology on 25 June(www.nature.com).US researchers combined two approaches to create a hybrid drug-a targeting moiety,called an aptamer,and an RNA-silencing moiety,called a small interfering RNA(siRNA).siRNA molecules can silence gene expression but,until now,researchers have had problems delivering them across cell membranes and targeting them to specific cells.