Congenital rubella syndrome: A continuing conundrum

摘要

A 32-year-old woman delivered monozygotic female twins vaginally at 34 weeks of gestation in November, 2011. This was her fourth pregnancy. She had received antenatal care elsewhere. During the first trimester she had an episode of fever and rash. The rest of the antenatal period was uneventful. Both the twins had respiratory distress and were admitted to our neonatal intensive care unit. Both were given empirical antibiotic therapy and were mechanically ventilated. Echocardio-gram showed that twin one had a patent ductus arteriosus; weight was appropriate for gestational age. Twin two was small for gestational age and was covered with diffuse purpura (figure), and had thrombocytopenia (platelet count 39x10~9/L) and retinitis. Radiography showed a radiolucent humerus bilaterally and intra-cranial calcifications.