Population Pharmacokinetics and Pharmacodynamics of Lumefantrine in Young Ugandan Children Treated With Artemether-Lumefantrine for Uncomplicated Malaria

Tchaparian Eskouhie; Sambol Nancy C.; Arinaitwe Emmanuel; McCormack Shelley A.; Bigira Victor; Wanzira Humphrey; Muhindo Mary; Creek Darren J.; Sukumar Nitin; Blessborn Daniel; Tappero Jordan W.; Kakuru Abel; Bergqvist Yngve; Aweeka Francesca T.; Parikh Sunil

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Population Pharmacokinetics and Pharmacodynamics of Lumefantrine in Young Ugandan Children Treated With Artemether-Lumefantrine for Uncomplicated Malaria

机译：蒿甲醚-卢美他汀治疗无并发症疟疾的乌干达年幼儿童中卢美替林的群体药代动力学和药效学

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Background. The pharmacokinetics and pharmacodynamics of lumefantrine, a component of the most widely used treatment for malaria, artemether-lumefantrine, has not been adequately characterized in young children.

机译：背景。在儿童中，尚未充分表征lumefantrine的药代动力学和药效学，该药物是最广泛使用的疟疾治疗药物Artemether-lumefantrine的组成部分。

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《The Journal of Infectious Diseases》 |2016年第8期|共9页
作者
Tchaparian Eskouhie; Sambol Nancy C.; Arinaitwe Emmanuel; McCormack Shelley A.; Bigira Victor; Wanzira Humphrey; Muhindo Mary; Creek Darren J.; Sukumar Nitin; Blessborn Daniel; Tappero Jordan W.; Kakuru Abel; Bergqvist Yngve; Aweeka Francesca T.; Parikh Sunil;
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正文语种 eng
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Malaria; population pharmacokinetics; lumefantrine; artemisinin combination therapy; antimalarial; nonlinear mixed effects modeling; pharmacodynamics; trimethoprim-sulfamethoxazole;

机译：疟疾;人群药代动力学;苦参碱;青蒿素联合治疗;抗疟药;非线性混合效应模型;药效学;甲氧苄氨嘧啶-磺胺甲恶唑;

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1. Population Pharmacokinetics and Pharmacodynamics of Lumefantrine in Young Ugandan Children Treated With Artemether-Lumefantrine for Uncomplicated Malaria [J] . Tchaparian Eskouhie, Sambol Nancy C., Arinaitwe Emmanuel, The Journal of Infectious Diseases . 2016,第8期

机译：蒿甲醚-卢美他汀治疗无并发症疟疾的乌干达年幼儿童中卢美替林的群体药代动力学和药效学
2. Artemether-Lumefantrine Pharmacokinetics and Clinical Response Are Minimally Altered in Pregnant Ugandan Women Treated for Uncomplicated Falciparum Malaria [J] . Nyunt Myaing M., Nguyen Vy K., Kajubi Richard, Antimicrobial agents and chemotherapy. . 2016,第3期

机译：在接受单纯性恶性疟疾治疗的乌干达孕妇中，蒿甲醚-卢美替宁的药代动力学和临床反应变化最小
3. Pharmacokinetic and pharmacodynamic characteristics of a new pediatric formulation of artemether-lumefantrine in African children with uncomplicated Plasmodium falciparum malaria. [J] . Djimde AA, Tekete M, Abdulla S, Antimicrobial agents and chemotherapy. . 2011,第9期

机译：一种新的儿科醚蒿甲醚-小花青素在非复杂性恶性疟原虫疟疾儿童中的药代动力学和药效学特征。
4. Interaction of subcutaneous lixisenatide 20 μg QD on pharmacokinetic and pharmacodynamic properties of oral ramipril 5 mg QD in steady state in young healthy males and females [C] . Dahmen R, Steinstraesser A, Poitiers F, European Association for Clinical Pharmacology and Therapeutics . 2011

机译：皮下丽西齐肽的相互作用20μgQD对年轻健康男性稳态口腔ramipril 5mg qd的药代动力学和药物动力学性质
5. Beta-lactam antimicrobial dosing optimization in obese patients compared to non-obese patients using population pharmacokinetic/pharmacodynamic approach. [D] . Chung, Eun Kyoung. 2015

机译：使用群体药代动力学/药效学方法，与非肥胖患者相比，肥胖患者的β-内酰胺抗菌药物剂量优化。
6. Population Pharmacokinetics and Pharmacodynamics of Lumefantrine in Young Ugandan Children Treated With Artemether-Lumefantrine for Uncomplicated Malaria [O] . Eskouhie Tchaparian, Nancy C. Sambol, Emmanuel Arinaitwe, -1

机译：蒿甲醚-卢美他汀治疗未复杂疟疾的乌干达年幼儿童中卢美替林的群体药代动力学和药效学
7. Population pharmacokinetics of lumefantrine in pregnant women treated with artemether-lumefantrine for uncomplicated Plasmodium falciparum malaria. [O] . Tarning, J, Mcgready, R, Lindegardh, N, 2009

机译：蒿甲醚-氟美汀治疗非复杂性恶性疟原虫疟疾的孕妇中氟美汀的总体药代动力学。

Population Pharmacokinetics and Pharmacodynamics of Lumefantrine in Young Ugandan Children Treated With Artemether-Lumefantrine for Uncomplicated Malaria

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