The translocation of α -helix chains through a nanopore is studied through Langevin dynamics simulations. The α -helix chains exhibit several different characteristics about their average translocation times and the α -helix structures when they transport through the nanopores under the driving forces. First, the relationship between average translocation times τ and the chain length N satisfies the scaling law, τ～ Nα, and the scaling exponent α depends on the driving force f for the small forces while it is close to the Flory exponent () in the other force regions. For the chains with given chain lengths, it is observed that the dependence of the average translocation times can be expressed as τ～ f-1/2 for the small forces while can be described as τ～f in the large force regions. Second, for the large driving force, the average number of α -helix structures N_h decreases first and then increases in the translocation process. The average waiting time of each bead, especially of the first bead, is also dependent on the driving forces. Furthermore, an elasticity spring model is presented to reasonably explain the change of the α -helix number during the translocation and its elasticity can be locally damaged by the large driving forces. Our results demonstrate the unique behaviors of α -helix chains transporting through the pores, which can enrich our insights into and knowledge on biopolymers transporting through membranes.
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