Highly selective fluorescent calix[4]areee chemoseesor for acidic amino acids in pure aqueous media

摘要

A fluorescent chemosensor based on a calix[4]arene derivative conjugated with four thiophene-cyanoary-lic acid groups at the upper rim displays high selectivity toward acidic amino acids in pure aqueous media through multiple H-bond interactions. The interactions of Asp/Glu with the chemosensor have been investigated by fluorescence and UV-Vis titrations, ESI-MS assay, ~1H NMR spectra, and molecular modeling method.