Azidation of anomeric nitro sugars: application in the synthesis of spiroaminals as glycosidaseinhibitors

摘要

6,5-Fused sugar-derived spiroaminals have been synthesized from the azido esters obtained via thenucleophilic substitution reactions of unstable Michael adducts derived from 1-nitro sugars. Most ofthe spiroaminals synthesized showed moderate but selective inhibitory activities toward someglycosidases.