Protecting-group-free Synthesis of Saccharide-terminated Polylactides by Direct Azidation of Unprotected Sugar and Click Chemistry

摘要

Glycolpolymers are interested in the field of materials science, medicinal chemistry, and biological chemistry. Especially, poly-L-lactide (PLLA) is a biobased polymer with biocompatibility and has been utilized as useful bioabsorbable materials. A lot of syntheses of saccharide-terminated PLLA were reported by ring-opening polymerization with partially protected saccharide derivatives having one free hydroxy group. However, this method needs multi-step process and laborious tasks including the protection and deprotection of hydroxy groups. Therefore, a facile synthetic method of saccharide-terminated PLLA that can be prepared without using any protection of hydroxy groups has been strongly demanded. In this study, we developed a facile synthesis of saccharide-terminated PLLA by direct synthesis of glycosyl azide and Click chemistry.