-18 Method for Synthesis of 18FFluoromethyl-substituted Radiopharmaceuticals by Using Selective Azidation and Precursor Scavenging

摘要

The present invention relates to a method for manufacturing a fluorine-18-labeled fluoromethyl-substituted radiopharmaceutical using selective azide substitution reaction. According to the present invention, the fluorine-18-labeled fluoromethyl-substituted radiopharmaceutical with high radiochemical purity can be synthesized even when HPLC separation and purification processes are omitted, thereby being able to reduce manufacturing time and manufacturing costs due to the HPLC process.