Dynamic kinetic resolution of racemic α-sulfonylaldehydes via asymmetric transfer hydrogenation

摘要

Hydrogen transfer reduction of α-sulfonylaldehydes using HCOOH-Et3N system as hydrogen source and (S,S)-TsDPEN-based Ru(II) as catalyst proceeds with dynamic kinetic resolution, providing optically active β-sulfonyl primary alcohols in moderate-to-good yields and up to 90% ee.