外消旋环氧化合物的水解动力学拆分研究

摘要

Product 1 is produced by reaction of racemic diaminocyclohexane with L-( + )-tartric acid, then it is condensed with 3,5-di-tert-butyl salicylaldehyde to give chiral Ligand 2, after which 2 reacts with Co(Oac)2 · 4H2O, and then it is converted to Salen-Co( Ⅲ ) (Oac) by oxidation. Research in hydrolytic kinetic resolution of racemic terminal epoxides by Salen-Co ( Ⅲ ) (Oac) catalyst is conducted, and the ee value of chiral diol is of up to 99. 7%.%外消旋环己二胺与L-(+)-酒石酸反应得化合物1,化合物1与3,5-二叔丁基水杨醛缩合,得到手性配体(化合物2),化合物2与Co(OAc)2·4H2O反应生成Salen-Co(Ⅱ)催化剂,然后经氧化得到Salen-Co(Ⅲ)(OAc)催化剂.末端环氧化合物在Salen-Co(Ⅲ)(OAc)催化下进行水解动力学拆分,所得的手性二醇ee值达到99.7％.