Gold-catalyzed synthesis of isoquinolines via intramolecular cyclization of 2-alkynyl benzyl azides

摘要

Intramolecular cyclization of 2-alkynyl benzyl azides in the presence of AuCl3 and AgSbF6 in THF under a pressured vial at 100 °C gives the corresponding isoquinolines in good yields. Similarly, the five-mem-bered analogs afford the corresponding isoquinolines.