A novel and direct synthesis of 1,3,4-oxadiazoles or oxazolines from carboxylic acids using cyanuric chloride/indium

摘要

Direct synthesis of various oxazolines and 1,3,4-oxadiazoles from carboxylic acids was achieved using cyanuric chloride/indium under very mild conditions.Five-membered heterocycles are privileged structures with utility in synthetic and medicinal chemistries. In general, oxazoline and oxadiazole building blocks have found widespread applications as synthetic intermediates, protecting groups, pharmacophores, and ester and amide surrogates.