Chelation control in the[3+3]annulation reaction of alkoxy-substituted 1,1-diacylcyclopropanes with 1,3-bis(trimethylsilyIoxy)-1,3-butadienes

摘要

Functionalized arenes were prepared by chelation-controlled'[3+3]cyclization/homo-Michael'reactions of 1,3-bis(trimethylsifyloxy)-1,3-butadienes with benzyloxy-or methoxy-substituted 1,1-diacylcyclopropanes.Highly substituted phenols are pharmacologically important molecules which occur in various natural products.Recently,we have reported the synthesis of functionalized phenols by TiCl4-mediated[3+3]cyclization of 1,3-bis(trimethylsilyloxy)-1,3-buta-dienes4 with 1,1-diacylcyclopropanes.