Preparation of N-alkyl-N'-carboalkoxy guanidines:unexpected effective trans-alkoxylation transforming the 2,2,2-trichloroethoxycarbonyl into various carbamates

摘要

A range of N-alkyl-N'-Boc guanidines was simply synthezized from monoprotected Boc-lH-pyrazole-l-carboxamidine by reaction with primary amines.Synthesis of the hindered (R)-N-methylbenzyl-N'-Troc guanidine was achieved from the corresponding thiourea by the action of ammonia.Transformation of the Troc group into others carbamate groups,including Boc,was simply obtained by refluxing in the appropriate alcohol.