an effective method for the preparation of (S) -3 - (1-dimethylamino) ethyl phenyl-N-ethyl-N-methyl-carbamate

摘要

A process for the preparation of rivastigmine of formula (I) ** ** Formula comprising: a) reacting 3- (1-dimethylaminoethyl) phenol of formula (V) with carbonyldiimidazole; ** ** Formula b) carrying out a stage in which reacted product of step a with ethylmethylamine in an organic solvent to obtain compound (II); ** ** Formula c) optionally resolving the compound (II) to give compound (I).