Controlling chemoselectivity-application of DMF di-t-butyl acetal in the regioselective synthesis of 3-monosubstituted indolizines

摘要

Among a number of DMF dialkyl acetals investigated for the regioselective synthesis of 3-acylindolizines,the di-t-butyl acetal,via its iminium intermediate readily formed in situ,provides the highest chemoselectivity for the intermolecular cyclization of picolinium salts.DMF di-t-butyl acetal was applied to the syntheses of a variety of 3-acylated indolizines including alkyl,aryl,and heteroaryl substituents.