Direct synthesis of novel 2-imino-l,3-selenazolidine derivatives from OMICRON-methanesulfonyl beta-amino alcohol hydrochlorides

摘要

Recently,we have reported that 4,5-dialkylsubstituted 2-imino-l,3-azolidine derivatives(1)strongly inhibit inducible nitric oxide synthase(iNOS).To our knowledge,only few methods have been reported for the synthesis of 4,5-dialkylsubstituted 2-imino-l,3-selenazolidine derivatives(2),which are the selenium analogue of 1.Herein,we report the direct synthesis of 2 from the corresponding OMICRON-methanesulfonyl beta-amino alcohol hydrochlorides using potassium selenocyanate and evaluation for the inhibitory activity against iNOS of the newly synthesized selenazolidine derivatives.