Facile synthesis of acyclic azanucleosides from N-pivaloyloxymethyl amides and sulfonamides:synthesis of aza-analogues of Ganciclovir

摘要

N-Pivaloyloxymethyl amides and sulfonamides,readily available from N-alkylation of both amides and sulfonamides with commercial chloromethyl pivaloate,were converted into acyclic azanucleosides via a one-pot base silylationucleoside coupling procedure.