Synthesis of 'difficult' peptide sequences:application of a depsipeptide technique to the Jung-Redemann 10- and 26-mers and the amyloid peptide Abeta(1-41)

摘要

Recently a 26-mer peptide 1 incorporating Ser and Thr was described as a 'difficult' sequence that could not be synthesized by standard methods.If the first Ser residue was used to incorporate a depsipeptide unit,the resulting hybrid was readily assembled.The 26-mer ester was then converted to the native peptide by an O->N acyl shift.The technique may be general for other systems containing appropriate Ser and Thr units and was demonstrated here for the case of the amyloid peptide Abeta(1-42).