Reusable biomacromolecule-Pd complex catalyzed C-C cross-coupling reactions via C-S cleavage of disulfides

摘要

A well-defined heterogeneous palladium catalyst, natural wool supported Pd(OAc)(2)-complex was found to be an effective catalyst for the C-S bonds cleavage and C-C bonds formation from 1,2-di(pyrimidin-2-yl)disulfane derivatives with arylboronic acids or terminal alkynes, giving the desired coupling products in moderate to excellent yields. The novel catalyst, which is stable and easy handling in experiment, was characterized by XPS, IR, SEM and ICP analysis. Subsequent analysis of the used catalyst after reaction revealed its negligible metal leaching and at least 10 rounds of recycled catalyzing capacity and wide range of substrate tolerance. (C) 2015 Elsevier Ltd. All rights reserved.