Chemoselective Carbon-Carbon Cross-Coupling via Palladium-Catalyzed Copper-Mediated C-S Cleavage of Disulfides

摘要

An efficient method for carbon-carbon bond formation is described. The process employs the palladium-catalyzed copper-mediated cross-coupling of diheteroaryl disulfides with arylboronic acids or alkynes to deliver C—C coupling products through unreactive C—S bond cleavage. The scope of the coupling reactions, including both the disulfides and arylboronic acids or alkynes, are documented.