Photoredox-Catalyzed Tandem Radical Cyclization of N?Arylacrylamides: General Methods To Construct Fluorinated 3,3-Disubstituted 2?Oxindoles Using Fluoroalkylsulfonyl Chlorides

摘要

Fluorinated radicals were generated from R_fSO_2Cl by photoredox catalysis under mild conditions, where R_f = n-C_4F_9, CF_3, CF_2H, CH_2F, CH_2CF_3, and CF_2CO_2Me. This method provided a general way to construct fluorinated 2-oxindoles from reaction with N-arylacrylamides via a proposed tandem radical cyclization process.