Attenuation of renal ischemia/reperfusion injury by acai extract preconditioning in a rat model

摘要

Aims: Renal ischemia/reperfusion (I/R) injury is highly associated with morbidity and mortality. Oxidative stress, inflammation, and apoptosis play pivotal roles in the development of renal dysfunction following renal I/R. Experimental studies have reported the effectiveness of many antioxidant and anti-inflammatory compounds against renal I/R injury. On the other hand, acai (Euterpe oleracea Mart. Palmae, Arecaceae) has recently gained considerable appreciation as a natural source of antioxidants. However, the effect of acai. extract has not been studied before on renal I/R Therefore, the present study was carried out to investigate the possible mechanisms of renal injury attenuation by acai extract in a rat renal I/R model.