Effects of Cyclen and Cyclam on Zinc(II)- and Copper(II)-Induced Amyloid beta-Peptide Aggregation and Neurotoxicity

Chen TT; Wang XY; He YF; Zhang CL; Wu ZY; Liao K; Wang JJ; Guo ZJ

首页> 外文期刊>Inorganic Chemistry: A Research Journal that Includes Bioinorganic, Catalytic, Organometallic, Solid-State, and Synthetic Chemistry and Reaction Dynamics >Effects of Cyclen and Cyclam on Zinc(II)- and Copper(II)-Induced Amyloid beta-Peptide Aggregation and Neurotoxicity

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Effects of Cyclen and Cyclam on Zinc(II)- and Copper(II)-Induced Amyloid beta-Peptide Aggregation and Neurotoxicity

机译：Cyclen和Cyclam对锌（II）和铜（II）诱导的淀粉样β肽聚集和神经毒性的影响

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Amyloid beta-peptide (A beta) aggregation is highly associated with Alzheimer's disease, which is facilitated by Zn2+ and Cu2+. Macrocyclic polyamine chelators cyclen and cyclam, can effectively protect A beta against precipitation induced by Cu2+ or Zn2+; the production of H2O2 mediated by Cu-A beta can also be inhibited by these chelators.

机译：淀粉样β肽（A beta）聚集与阿尔茨海默氏病高度相关，而Zn2 +和Cu2 +促进了这种疾病。大环多胺螯合剂cycln和cyclam可以有效保护A beta免受Cu 2+或Zn 2+引起的沉淀;这些螯合剂也可以抑制由Cu-Aβ介导的H2O2的产生。

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《Inorganic Chemistry: A Research Journal that Includes Bioinorganic, Catalytic, Organometallic, Solid-State, and Synthetic Chemistry and Reaction Dynamics》 |2009年第13期|共9页
作者
Chen TT; Wang XY; He YF; Zhang CL; Wu ZY; Liao K; Wang JJ; Guo ZJ;
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正文语种 eng
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aggregation; precipitation; production;

机译：聚集;沉淀;生产;

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1. Effects of Cyclen and Cyclam on Zinc(II)- and Copper(II)-Induced Amyloid beta-Peptide Aggregation and Neurotoxicity [J] . Chen TT, Wang XY, He YF, Inorganic Chemistry: A Research Journal that Includes Bioinorganic, Catalytic, Organometallic, Solid-State, and Synthetic Chemistry and Reaction Dynamics . 2009,第13期

机译：Cyclen和Cyclam对锌（II）和铜（II）诱导的淀粉样β肽聚集和神经毒性的影响
2. Trace copper(II) or zinc(II) ions drastically modify the aggregation behavior of amyloid-beta1-42: an AFM study. [J] . Innocenti M, Salvietti E, Guidotti M, Journal of Alzheimer's disease: JAD . 2010,第4期

机译：微量铜（II）或锌（II）离子极大地改变了淀粉样β1-42的聚集行为：一项AFM研究。
3. Metal Chelates to Prevent or Clear the Deposits of Amyloid beta-peptide(1-40) induced by Zinc(II) Chloride [J] . Yuichi Sutoh, Satoshi Nishjno, Yuzo Nishida Chemistry Letters . 2005,第2期

机译：金属螯合物可防止或清除氯化锌（II）诱导的淀粉样β肽（1-40）沉积
4. Chitosan- Copper(II) , Zinc(II) and Ferric(II) Complexes as Antimicrobial Agent: Synthesis, Characterization and Structure- Activity Study [C] . Xiaohui Wang, Yumin Du, Fei Huang Polymeric Materials: Science Engineering Symposia . 2005

机译：壳聚糖 - 铜（II），锌（II）和铁（II）复合物作为抗微生物剂：合成，表征和结构 - 活性研究
5. Amyloid beta-peptide (1-42)-mediated oxidative stress and neurotoxicity: I. The role of methionine 35. II. Proteomic identification of specifically oxidized proteins in models of Alzheimer's disease. [D] . Boyd-Kimball, Debra Lynn. 2004

机译：淀粉样β-肽（1-42）介导的氧化应激和神经毒性：I.蛋氨酸的作用35. II。蛋白质组学鉴定阿尔茨海默病模型中特定氧化的蛋白质。
6. The protective effects of TanIIA on neurotoxicity induced by β-amyloid protein through the Cdk5/P35 pathway in cultured primary neurons [O] . Lili Shi, Weina Yang, Yihua Qian, 2012

机译：TanIIA通过Cdk5 / P35途径对培养的原代神经元中β-淀粉样蛋白诱导的神经毒性的保护作用
7. The protective effects of TanIIA on neurotoxicity induced by β-amyloid protein through the Cdk5/P35 pathway in cultured primary neurons [O] . 2012

机译：TanIIA通过Cdk5 / P35途径对培养的原代神经元中β-淀粉样蛋白诱导的神经毒性的保护作用
8. Inorganic Coordination Polymers. XXI. Manganese (II),Cobalt (II),Nickel (II),Copper (II),and Zinc (II) Bis(N-Phenylaminomethyl) Phosphinates. Effects of Coordinating Side Groups. [R] . eichelberger, j. l. gillman, h. d. 1977

机译：无机配位聚合物。 XXI。锰（II），钴（II），镍（II），铜（II）和锌（II）双（N-苯基氨基甲基）次膦酸盐。协调边群的影响。

Effects of Cyclen and Cyclam on Zinc(II)- and Copper(II)-Induced Amyloid beta-Peptide Aggregation and Neurotoxicity

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