Synthesis and Antibacterial Activity of Hydrazone Derivatives Bearing 3-(6,7-Dihydrothieno[3,2-c]pyridin-5(4H)-ylsuIfonyl)benzoicacid Scaffold

摘要

The present work describes the synthesis and antibacterial activity of 3-(6,7-dihydrothieno[3,2-c]pyridm-5(4H)-ylsulfonyl)benzohydrazide derivatives (7a-p) prepared from commercially available 4,5,6,7-tetrahydrothieno[3,2-c]pyridine (1). They were characterized by ~1H NMR, IR and mass spectral analysis. The synthesized compounds 7a-p, were tested against Gram negative and Gram positive bacterial strains viz; (i) Escherichia coli (MTCC 443), (ii) Pseudomonas aeruginosa (MTCC 424) (iii) Staphylococcus aureus (MTCC 96) and (iv) Streptococcus pyogenes (MTCC 442) using agar well diffusion method. Compounds 7g (R = 2-OH, 4-OCHF2), 7h (R = 2-NO2), 7i (R = 3-NO2). 7j (R = 4-NO2) and 7n (4-OH) displayed excellent antibacterial activity (zone of inhibition: 25-32 mm) against both the Gram positive and Gram negative bacterial strains. Compounds 7f (R = 2-F, 3-C1), 7k (R = 2-OMe), 71 (R = 4-OMe), 7m (R = 4-OEt), 7o (R = 3-OMe), 7p (R = 3,4-OEt) showed good antibacterial activity (zone of inhibition: 19-26 mm).