Novel Route for Synthesis of (S)-l-Benzyl-6-oxopiperidine-2-carboxylic Acid and its Crystal Structure

摘要

A piperidine carboxylic acid was synthesized and the structure of compound was confirmed by spectral methods and the X-ray diffraction experiment was employed to investigate the crystal structure of (5)-1-benzyl-6-oxopiperidine-2-carboxylic acid. In the crystal structure of the title compound 5, C_(13)H_(15)NO3, one molecule creates independent part of the unit cell. The compound crystallizes in the orthorhombic space group P2,2,2,with a = 8.1384(3), b = 10.5953(3), c = 14.1104(3) A and a = β = y = 90°. The piperidine ring exhibits a chair conformation. The mean plane of the piperidine ring makes a dihedral angle of 61.10(9)° with the planar benzyl ring. The crystal structure packing of the compound is controlled by strong intermolecular O-H-O hydrogen bonds and weak C-H--0 intramolecular interactions.