Reactivity of β-Cetoesters Compounds, Synthesis of Nitrogenated Heterocycles (Derivatives of Tetrahydroacridin-9-ones and Pyrimidinone) and Biological Properties of Pyrimidinone Derivatives

摘要

Ethyl 2-oxocyclohexanecarboxylate has undergone smooth condensation with arylamines under ethanol. The corresponding β-enaminoesters compounds were obtained in good yields. These compounds were then refluxed in biphenyl ether to attain the respective substituted tetrahydroacridin. The reaction of 2-amino-5,6-dimethylbenzimidazole with P-cetoesters gave access to an efficient synthesis of pyrimidinone derivatives in excellent yield. A series of novel heterocycles were prepared. Biological properties of compounds 11-14 have been distinctively evolved.