Mechanism of action of the Adiana((R)) device: a histologic perspective.

摘要

BACKGROUND: The study was conducted to confirm the mechanism of action of the Adiana permanent contraception device by means of histologic analysis of long-term specimens. STUDY DESIGN: Fifteen specimens were obtained from eight subjects undergoing hysterectomy 2 to 4 years after the Adiana procedure. Serial sections were stained with hematoxylin and eosin, as well as epithelial membrane antigen immunostain. RESULTS: A normal foreign body reaction with minimal chronic inflammatory changes was observed in all specimens. Immunostaining for epithelial membrane antigen was absent in the interstitial tissue surrounding the matrix. CONCLUSION: Histologic analysis of long-term specimens supports the mechanism of action of the Adiana permanent contraception device.