Taking video across the diffraction barrier

摘要

Investigation of the chemical and physical details of living cells has advanced dramatically in recent years.But to date,direct nano-scopic observation of intracellular dynamics has remained beyond reach.Now,Stefan Hell and colleagues at the Max Planck Institute for Biophysical Chemistry and the European Neuroscience Institute (both in Germany) have developed an optical system capable of video-rate (28 frames/s) imaging with <62 nm resolution (Science 2008,DOI 10.1126/science.ll54228).